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Arginine for Peyronie’s Disease Treatment

Arginine for Peyronie’s Disease Treatment

Arginine for Peyronie's DiseaseArginine for Peyronie’s Disease Treatment is an amino acid the body makes naturally, but it is also found in foods that contain protein. Research indicates arginine can be beneficial for conditions such as clogged arteries, heart disease, erectile dysfunction, and other health problems that involve blood flow.

Studies of Arginine for Peyronie’s Disease Treatment

Studies of the effect of Arginine for Peyronie’s Disease Treatment are limited. A rat study showed arginine given to the animals in their water helped reduce plaque size and the ratio of plaque-building components (collagen and fibroblasts). (Valente 2003)

In another study, Arginine for Peyronie’s Disease Treatment was used along with oral pentoxifylline and injections of verapamil in men who used penile traction for at least two hours per day. Overall, the authors reported there was “a trend toward measured curvature improvement” and a significant gain in stretched penile length using this combination therapy. (Abern 2012)

Dose and Side Effects of Arginine for Peyronie’s Disease Treatment

The suggested dose of arginine is 1 gram twice daily. Arginine is considered safe when used for short periods, but it should not be taken if you are using medications to lower blood pressure, treat erectile dysfunction (e.g., sildenafil), or increase blood flow to the heart. Side effects of arginine may include abdominal pain, bloating, blood abnormalities, diarrhea, low blood pressure, and worsening of allergies or asthma.


Abern MR et al. Combination of penile traction, intralesional verapamil, and oral therapies for Peyronie’s disease. J Sex Med 2012 Jan; 9(1): 288-95 Arginine for Peyronie’s Disease Treatment

Valente EG et al. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie’s fibrotic plaque and related fibroblast cultures. Nitric Oxide 2003 Dec; 9(4): 229-44 – Arginine for Peyronie’s Disease Treatment

About Dr. Larry Lipshultz, M.D.

Dr. Lipshultz is Professor of Urology and Chief of the Division of Male Reproductive Medicine and Surgery at the Baylor College of Medicine in Houston, Texas . He is an internationally acclaimed fertility specialist and a pioneer in the field of urologic microsurgery, specializing in male infertility, erectile dysfunction, microsurgery, genetic causes of infertility, and age-related changes in male hormone levels (androgen replacement). He was a founder of the Society for the Study of Male Reproduction and is a Past President of the American Society for Reproductive Medicine. In addition, he has served on the FDA Advisory Committee for Reproductive Health Drugs. He was the first AUA Research scholar and was awarded the prestigious Hugh Hampton Young Award at the 2005 AUA Annual Meeting. More on Dr. Lipshultz

Site last updated 28 October, 2016



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