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Drugs for Erectile Dysfunction

drugs for erectile dysfunctionDrugs for Erectile Dysfunction

The five main drugs for erectile dysfunction are sildenafil (Viagra), vardenafil (Levitra, Staxyn), avanafil (Stendra), and tadalafil (Cialis). All of these medications belong to the same drug class –phosphodiesterase inhibitors—and they work in a similar way: by enhancing the effects of nitric oxide, a chemical that relaxes the muscles in the penis. Once the muscles relax, blood flow to the penis increases and allows for nature to take its course—an erection in response to sexual stimulation. Read More on How Erectile Dysfunction Drugs Work

It’s important to understand that taking these drugs for erectile dysfunction does not guarantee you will get an erection; they simply allow an erection to happen with the added ingredient of physical and/or psychological stimulation. Many men experience an improvement in erectile function when using these medications regardless of the cause of their impotence.

Drugs for Erectile Dysfunction: What is the Difference?

Although these drugs are in the same class, they do differ in some ways. Which one is best for you? Your doctor will make that call, yet you should know that no study has directly compared these drugs for erectile dysfunction, so for now no one can say for certain which drug is best for certain types of men.

  • Viagra-Sildenafil: The dosing range is 25 to 100 mg once daily, with 50 mg being the most common dose. Viagra should be taken about one hour before sexual activity, although the range can be from 30 minutes to 4 hours. The most common side effects (and the percentage of men who typically experience them) are headache (16%), flushing (10%), heartburn (7%), stuffy nose (4%), urinary tract infection (3%), abnormal vision (3%), diarrhea (3%), dizziness (2%), and rash (2%). Seek medical advice if any of these symptoms become severe or persistent.
  • Levitra -Vardenafil: The range of dosing is 5 mg to 2o mg, depending on your needs. Vardenafil can be taken once daily. The most common side effects seen in flexible dosing studies (when men can change their dose depending on side effects) are headache (15%), flushing (11%), sneezing (9%), heartburn (4%), sinusitis (3%), dizziness (2%), and nausea (2%).
  • Staxyn – Vardenafil: Staxyn is a new orally disintegrating form of vardenafil, which was approved by the FDA in June 2010 and released to the market  in the United States by the end of that year.  Although Staxyn and Levitra both contain the generic drug vardenafil, a 10-mg film coated tablet of Levitra is not interchangeable with a 10-mg dose of Staxyn because the latter provides higher systemic exposure than Levitra. The maximum dose of Staxyn is one tablet daily. The most common side effects are headache (14%), flushing (7%), nasal congestion (3%), heartburn (3%), dizziness (2%), and back pain (2%).
  • Cialis -Tadalafil: The range of dosing is 5 mg to 20 mg, depending on your needs. This drug has been shown to improve erectile function for up to 36 hours. Studies show that the most common side effects associated with dosages of 5 mg are: headache (11%), heartburn (4%), back pain (3%), muscle pain (1%), stuffy nose (2%), flushing (2%), and limb pain (1%).
  • Stendra – Avanafil: Dosing ranges from 50 to 200 mg. Stendra can work as fast as 15 minutes, and the effects of the drug may least more than 6 hours in some men. The most common side effects are flushing, headache, nasal congestion, and runny nose.

When Not to Take Drugs for Erectile Dysfunction

Drugs for erectile dysfunction should always be taken according to the manufacturers’ instructions. Manufacturers make a number of warnings about when not to take drugs for erectile dysfunction, including the following reasons:

· If you take nitrate drugs for angina, such as nitroglycerin, isosorbide mononitrate, isosorbide dinitrate
· If you take blood thinning medications
· If you take certain types of alpha-blockers for blood pressure or an enlarged prostate

Also, if you have any of the following health conditions, you are strongly urged to talk to your doctor before taking any drugs for erectile dysfunction:

· Severe heart disease or heart failure
· Stroke
· Very low blood pressure
· Uncontrolled high blood pressure
· Uncontrolled diabetes
· Liver or kidney disease
· A blood cell disorder such as sickle cell anemia, leukemia, or multiple myeloma
· Hemophilia
· A stomach ulcer
· Retinitis pigmentosa (an inherited eye condition)

There are also many other side effects and warnings associated with taking PDE5 drugs. Always consult your doctor before taking any of these drugs for ED.

What’s Wrong With 4-Hour Erections?

The advertisements on TV for the major ED drugs always advise you to “seek medical attention if you have an erection lasting longer then 4-hours”. One side effect from drugs to treat ED can be a prolonged erection (known as priapism; an erection lasting longer than four hours). A prolonged erection may also be caused by other treatments such as injections and MUSE suppositories.

Priapism is a serious medical condition, because the penis is deprived of oxygen, which damages and destroys erectile tissue. Thus warnings about seeking immediate medical attention should be taken seriously. Often times, your doctor may give you an information card similar to the Sloan-Kettering Wallet Card for patients using penile injections. This card details the serious nature of priapism and advises the attending medical professional of treatment options and other information.

Created: November 23, 2010

Site last updated 26 October, 2016



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