Hesperidin Health Benefits
Hesperidin health benefits include an ability to promote healthy blood vessels and blood flow, and possibly anticancer properties. The white parts and pulps of oranges, grapefruit, and other citrus are the main sources of hesperidin.
Hesperidin is a bioflavonoid found only in citrus, with sweet citrus and tangelos believed to be the richest sources. Some people take advantage of hesperidin health benefits in the form of a supplement, as the nutrient seems to improve the health of capillaries. There are several studies pointing to the possibility that hesperidin has anticancer properties, including research in colon (Aranganathan 2009), liver (Yeh 2009), and pancreatic cancer (Patil 2009).
In a recent study from the University of California, Santa Barbara, scientists evaluated the effects of hesperidin on breast cancer cells. They also looked at the impact of hesperidin on both androgen-independent and androgen-dependent prostate cancer cells. Hesperidin inhibited the proliferation of the breast cancer cells but not the androgen-independent prostate cancer cells. Hesperidin did, however, have an impact on androgen-dependent prostate cancer cells. This suggested that hesperidin health benefits may include help with prostate cancer. However, more research is needed in the mechanisms involved in different prostate cancer cell lines. (Lee 2010)
How To Take Hesperidin
Like other bioflavonoids, hesperidin health benefits are most appreciated when it is taken along with vitamin C and other bioflavonoids, just like it appears in nature. That’s why hesperidin is frequently one of the ingredients in a bioflavonoid supplement. Hesperidin is also available alone as a powder or capsule. Because hesperidin, like other bioflavonoids, reduces blood platelet stickiness, anyone who is taking blood thinners should not take hesperidin until they speak with a healthcare professional. The amount of hesperidin consumed depends on the strength of the supplement and the reason for taking it.
Aranganathan S, Nalini N. Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone) on 1,2-dimethylhydrazine induced colon carcinogenesis. Food Chem Toxicol 2009 Oct; 47(10): 2594-600.
Lee CJ et al. Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells. Phytother Res 2010 Jan; 24 Suppl:S15-19
Patil JR et al. Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells. J Agric Food Chem 2009 Nov 25; 57(22): 10933-42.
Yeh MH et al. Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. Toxicol Lett 2009 Feb 10; 184(3): 204-10.